Purpose: Eggs and cow\'s milk’s allergy is the most common allergy in children. The purpose of this study was to evaluate the change of specific IgE (sIgE) concentrations to egg and cow’s milk (CM) in children for 2 years. Methods: In this retrospective study, children 12 months of age with atopic dermatitis (AD) were enrolled from March 2015 to August 2017. The 147 children conducted SCORAD score, total immunoglobulin E (IgE), and specific IgE (sIgE) to eggs and CM three times [first, second (6~12 month later), and third (12~24 month later) visit day]. The children with AD were categorized into three groups: sensitization to eggs (n=35), sensitization to CM (n=36), and, sensitization to egg and CM (n=76). Results: No significant differences were observed in gender, age at AD onset, and duration of AD among three groups. Significant differences were observed in SCORAD score and PLT levels among three groups. Compared with eggs and CM group, significantly more patients in eggs and CM group had positive test results for methicillin-resistant Staphylococcus aureus (MRSA) (p = 0.003). The eggs-sIgE and CM-sIgE concentration had no significant differences among three groups at first visit day, but significant differences at second and third visit day. In the study period, 19% of patients with no sensitization to eggs and CM at an average age of 35 months old. Conclusions: Our results indicate that infant with sensitization to eggs and CM had a tendency to persistent compared to infant with sensitization to eggs or CM. The data also suggest that sensitization to eggs and CM may associate with MRSA infection